It is located on the Tampa Reservation off of Interstate 4, just east of Tampa, Florida. Seminole Hard Rock Hotel & Casino Tampa is a gaming complex and hotel that opened in 2004. ( February 2021) ( Learn how and when to remove this template message)ĥ223 North Orient Road, Tampa, Florida 33610 Please help to improve this article by introducing more precise citations. This article includes a list of general references, but it lacks sufficient corresponding inline citations.